View abstract. Intern Med 2001;40:764-8. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. [Study on effect and mechanism of scutellaria baicalensis stem-leaf total flavonoid in regulating lipid metabolism]. B., and Bae, K. H. Pharmacological effects of methanolic extract from the root of Scutellaria baicalensis and its flavonoids on human gingival fibroblast. View abstract. A specific combination product called flavocoxid (Limbrel, Primus Pharmaceuticals) that contains Baikal skullcap was safely used in research studies lasting up to 12 weeks. Planta Med 2011;77(5):455-460. Mol Pharmacol 2001;60(3):507-513. Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others. Int J Cancer 9-10-2003;106(4):559-565. 2019;49(4):544-546. J Agric Food Chem 12-3-2003;51(25):7276-7279. J Cell Biochem 12-15-2010;111(6):1629-1641. Induction of apoptosis by total flavonoids from. Toxicol.Appl.Pharmacol 8-1-2011;254(3):221-228. View abstract. Arch Dis Child 1993;68:468-71. Zhou, X., Zhang, Q., Liang, H., Jiang, Y., Wang, X., Wang, B., and Zhao, Y. Bonham, M., Posakony, J., Coleman, I., Montgomery, B., Simon, J., and Nelson, P. S. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. In Vivo 2004;18(4):497-503. Int Immunopharmacol. View abstract. However, it is not known if the herb would exert similar effects by itself, and cases of hepatotoxicity with some supplements have been reported(18)(24). Some medications are moved by pumps into cells. View abstract. Natural Product Sciences 2008;14(3):182-186. View abstract. High temperature effects on flavones accumulation and antioxidant system in Scutellaria baicalensis Georgi cells. Pharmacogenomics of human OATP transporters. Talk with your healthcare provider before using Baikal skullcap if you are taking medications used for lowering cholesterol. 2-25-2009;122(1):20-27. Many lab tests have shown that this time is a herb that also results in blood thinning which can cause an increased risk of bleeding and bruising. Kim, B. R., Kim, D. H., Park, R., Kwon, K. B., Ryu, D. G., Kim, Y. C., Kim, N. Y., Jeong, S., Kang, B. K., and Kim, K. S. Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. View abstract. Huang, R. L., Chen, C. C., Huang, H. L., Chang, C. G., Chen, C. F., Chang, C., and Hsieh, M. T. Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis. Cao, H., Jiang, Y., Chen, J., Zhang, H., Huang, W., Li, L., and Zhang, W. Arsenic accumulation in Scutellaria baicalensis Georgi and its effects on plant growth and pharmaceutical components. 2011;39(1):217-224. Comparison of anti-inflammatory and anti-nociceptive activities of Curcuma wenyujin Y.H. Wang, J., Yu, Y., Hashimoto, F., Sakata, Y., Fujii, M., and Hou, D. X. Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells. Shieh, D. E., Cheng, H. Y., Yen, M. H., Chiang, L. C., and Lin, C. C. Baicalin-induced apoptosis is mediated by Bcl-2-dependent, but not p53-dependent, pathway in human leukemia cell lines. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. Most studies have been done in the lab rather than in humans, and suggest anti-inflammatory and antioxidant activity. You may ask and answer a query. 2004;50(3):279-285. View abstract. Baikal skullcap can also affect most peoples blood sugar levels, but people with diabetes can get negative results with the herb. View abstract. Phytother Res 2000;14:210-2. Thanks to its salicin content, willow bark is often touted as Ye, F., Jiang, S., Volshonok, H., Wu, J., and Zhang, D. Y. Molecular mechanism of anti-prostate cancer activity of Scutellaria baicalensis extract. 2020;318(1):E52-E61. Lixuan, Z., Jingcheng, D., Wenqin, Y., Jianhua, H., Baojun, L., and Xiaotao, F. Baicalin attenuates inflammation by inhibiting NF-kappaB activation in cigarette smoke induced inflammatory models. Adv Ther 2010;27:731-42. Neo-clerodane diterpenoids also have demonstrated anticancer(24) and antiviral(25) activities. View abstract. Baikal skullcap might also lower blood sugar. Liu, W., Mu, R., Nie, F. F., Yang, Y., Wang, J., Dai, Q. S., Lu, N., Qi, Q., Rong, J. J., Hu, R., Wang, X. T., You, Q. D., and Guo, Q. L. MAC-related mitochondrial pathway in oroxylin-A-induced apoptosis in human hepatocellular carcinoma HepG2 cells. View abstract. View abstract. Cancer Lett. Yim, J. S., Kim, Y. S., Moon, S. K., Cho, K. H., Bae, H. S., Kim, J. J., Park, E. K., and Kim, D. H. Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora. Lai, M. Y., Hsiu, S. L., Chen, C. C., Hou, Y. C., and Chao, P. D. Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans. Monday through Friday, 8 a.m. to 6 p.m. (Eastern time), Monday through Friday, 9 a.m. to 5 p.m. (Eastern time), Monday to Friday, 8 a.m. to 6 p.m. (Eastern time). Konoshima, T., Kokumai, M., Kozuka, M., Iinuma, M., Mizuno, M., Tanaka, T., Tokuda, H., Nishino, H., and Iwashima, A. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. This information may not fit your specific health circumstances. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. Cell Mol Biol Res 1993;39(2):119-124. J Ethnopharmacol. View abstract. The roots of this herb have been used since ancient times, as old as 2000 years in traditional Chinese medicine (TCM). Small studies in humans suggest that S. barbata may benefit patients with advanced breast cancer. S. barbata is an herb found in Korea and southern China. View abstract. View abstract. 4-1-2011;492(2):76-79. Involvement of p53 in oroxylin A-induced apoptosis in cancer cells. Chen et C. Ling and Scutellaria baicalensis Georgi. Biol Pharm Bull 2003;26(1):79-83. Taking Baikal skullcap along with some medications that are changed by the liver might increase the effects and side effects of some medications. Have a cup of it daily. 73.^ Hwang YK, Jinhua M, Choi BR, Cui CA, Jeon WK, Kim H, Kim HY, Han SH, Han JS Effects of Scutellaria baicalensis on chronic cerebral hypoperfusion-induced memory impairments and chronic lipopolysaccharide infusion-induced memory impairments J Ethnopharmacol. The effect of supplementation with Scutellaria baicalensis on hepatic function. Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages. Gasiorowski, K., Lamer-Zarawska, E., Leszek, J., Parvathaneni, K., Yendluri, B. 2002;51(6):277-283. Tell your healthcare providers about any dietary supplements youre taking, such as herbs, vitamins, minerals, and natural or home remedies. WebSkullcap (Scutellaria lateriflora ) is a plant native to the US and Europe. View abstract. View abstract. Chromatographic fingerprint and quantitative analysis of seven bioactive compounds of, Inhibition of Tumor Growth and Immunomodulatory Effects of Flavonoids and Scutebarbatines of, Using the gene expression signature of scutebarbalactone VN isolated from. J Dermatol Sci 2007;46(1):31-40. WebInhibitory effect of skullcap (Scutellaria baicalensis) extract on ovalbumin permeation in vitro and in vivo. J Ethnopharmacol. View abstract. Toxicology 3-4-2009;257(1-2):80-85. Monitor your blood pressure closely. An herbal supplement containing S. baicalensis reduced symptoms of osteoarthritis(22). View abstract. Chinese Journal of Gerontology 2010;30(7):926-928. Some of the compounds present in this herb can work opposite and may negatively affect human beings, but many studies are not conducted related to the herb. Chinese journal of modern developments in traditional medicine 1990;10(5):278-9. WebBaicalin extracts have strong anti-inflammatory effects. 1998;61(2):54-56. Watanabe S, Kitade Y, Maski T, Nishioba M, Satoh K, Nishino H. Effects of lycopene and Sho-saiko-to on hepatocarcinogenesis in a rat model of sponstaneous liver cancer. Luna-Bastante L, Gatica-Ortega ME, Pastor-Nieto MA, et al. 2020 Apr;82(4):253-254. Different extracts of this herb have been found to kill cancer cells in the body, but human research is pending in this field. There are a number of different names that people use for Baicalin. T As one of the most popular and versatile herbs used in China, Scutellaria baicalensis (S. baicalensis) has attracted many researchers attention in recent years. Baikal skullcap might change how quickly the liver breaks down these medications. View abstract. J Ethnopharmacol 2005;98:295-300. View abstract. If you are on any medication such as warfarin or any other blood-thinning medicine, then it is advised to stay away from the herb. Lee BH, Lee SJ, Kang TH, et al. View abstract. Acta Pharmacol Sin. The root of Scutellaria baicalensis (SB) traditionally used for fever clearance and detoxification possesses various bioactivities including anticancer effects. WebScutellaria baicalensis Root Dry No Data Extract 100 4. September 2012. You are encouraged to report negative side effects of prescription drugs to the FDA. Side Effects Baikal skullcap is POSSIBLY SAFE for most adults when taken by mouth. J Nat Prod 2009;72(9):1616-1619. View abstract. Drug Metab Dispos 2005;33:537-46. It's one of the most commonly used thickeners and emulsion stabilizers.If the product is too runny, a little xanthan gum will make it more gel-like. Therapeutic Research Faculty 2020. It is thought that the active chemicals in Baikal skullcap might be able to decrease inflammation, stop tumor growth, and prevent tumor cell reproduction. Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of. Zhongguo Zhong.Yao Za Zhi 2001;26(11):768-769. Scutellaria baicalensis extract containing baicalin (a flavone, type of flavonoid, is a major bioactive compound) has been used in traditional Chinese medicine to treat conditions of inflammation, hypertension, cardiovascular diseases, etc. A Scutellaria Baicalensis Root Extract trade name mixture (30% ethanol extract) is reported to contain flavonoid compounds. View abstract. Wu X, Zhang H, Salmani JM, et al. 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